CURRICULUM VITAE

Steven B. Vik

Educational Training:

1975 California Institute of Technology, Pasadena, CA
B.S. (Chemistry)

1980 University of Oregon, Eugene, OR
Ph.D. (Chemistry - Biochemistry)

Positions Held:

1980-82 Research Associate, Department of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, CA

1982-83 Visiting Research Scholar, Chinese Academy of Sciences, Institute of Zoology, Department of Cell Biology, Beijing, People's Republic of China

1983-87 Postdoctoral Research Fellow, Department of Biological Sciences, Stanford University, Stanford, CA

1987-1993 Assistant Professor, Department of Biological Sciences, Southern Methodist University, Dallas, TX

1993-1999 Associate Professor, Department of Biological Sciences, Southern Methodist University, Dallas, TX

1999-present Professor, Department of Biological Sciences, Southern Methodist University, Dallas, TX

2008-2010 Guangbiao Professor, Zhejian University, Department of Tea Science, Hangzhou, China

Societies

American Association for the Advancement of Science
American Chemical Society
American Society for Microbiology
American Society for Biochemistry and Molecular Biology
Protein Society
Sigma Xi

Awards:

Postdoctoral Research Fellowship, American Heart Association, California Affiliate, 1981-1982.

Research Fellowship, National Program for Advanced Study and Research in China, Committee on Scholarly Communications with the People's Republic of China, 1982-1983.

Postdoctoral Research Fellowship, Program in Cancer Biology, Stanford University, 1983-1984.

Outstanding Research Award, Southern Methodist University Chapter of Sigma Xi, 1993.

Ford Research Fellowship, Southern Methodist University, 2008.

Research Grants

National Institutes of Health Research Grant, RO1-40508, "Structure-Function Studies of the E. coli F1Fo ATPase," Southern Methodist University, 1988-2003.

National Institutes of Health Supplement to RO1-40508 to support a minority undergraduate (Douglas Patton), 1992-1994.

National Institutes of Health Supplement to RO1-40508 to support an undergraduate, Cindy Kluender (SURE program), 1993.

Welch Foundation, N-1378, "Metal Chelate Mediated Proteolysis of Membrane Proteins," Southern Methodist University, 1997-2000

Welch Foundation, N-1378, "Chemical Proteolysis and Cross-linking of Membrane Proteins," Southern Methodist University, 1997-2000

American Heart Association, 0455139Y,  “Quinone Binding Sites in Complex I and their possible role in disease”, Southern Methodist University. 2004-2006

 National Institutes of Health Research Grant, RO1-40508, "Structure-Function Studies of the E. coli F1Fo ATPase," Southern Methodist University, 2005-2009 

 Welch Foundation, N-1378, “Analysis of Supercomplexes of Membrane-bound Enzymes”, Southern Methodist University, 2006-2009 

Editorial Board
Journal of Biological Chemistry  2005-2010

Selected Publications

Vik, S.B., Georgevich, G., and Capaldi, R.A. (1981) Diphosphatidylglycerol is required for optimal activity of beef heart cytochrome c oxidase. Proc. Natl. Acad. Sci. USA 78: 1456-1460.

Vik, S.B. and Hatefi, Y. (1981) The possible occurrence and role of an essential histidyl residue in succinate dehydrogenase. Proc. Natl. Acad. Sci. USA 78, 6749-6753.

Vik, S.B. and Simoni, R.D. (1987) Assembly of the F₁F_o ATPase from E. coli with mutant F_o subunits. Partial purification and immunoprecipitation of F₁F_o complexes. J. Biol. Chem. 262: 8340-8346.

LaRoe, D.J. and Vik, S.B. (1992) Mutations at Glu-32 and His-39 in the e subunit of the E. coli F₁F_o ATP synthase affect its inhibitory properties. J. Bacteriol. 174: 633-637.

Wang, S. and Vik, S.B. (1994) Single amino acid insertions probe the a subunit of the E. coli F₁F_o ATP synthase. J. Biol. Chem. 269, 3095-3099.

Vik, S.B. and Antonio, B.J. (1994) A mechanism of proton translocation by F₁F_o ATP synthases suggested by double mutants of the a subunit. J. Biol. Chem. 269: 30364-30369.

Xiong, H. and Vik, S.B. (1995) Alanine-scanning mutagenesis of the epsilon subunit of the F₁F_o ATP synthase from Escherichia coli reveals two classes of mutants, J. Biol. Chem . 270: 23300-23304.

Vik, S.B., Patterson, A.R. and Antonio, B.J. (1998) Insertion Scanning Mutagenesis of the a Subunit of the F₁F_o ATP Synthase Near His 245 and Implications on Gating of the Proton Channel, J. Biol. Chem. 273: 16229-16234.

Long, J.C., Wang, S. and Vik, S.B. (1998) Membrane Topology of the a Subunit of the F₁F_o ATP Synthase as Determined by Labeling of Unique Cysteine Residues J. Biol. Chem. 273: 16235-16240.

Xiong, H., Zhang, D. and Vik, S. B. (1998) Subunit Epsilon of the E. coli ATP Synthase: Novel insights into Structure and Function from Analysis of Thirteen Mutant Forms, Biochemistry 37: 16423-16429

Wada, T., Long, J. C., Zhang, D. and Vik, S. B., (1999) A Novel Labeling Approach Supports the Five-transmembrane Model of Subunit a of Escherichia coli ATP Synthase, J. Biol. Chem., 274: 17353-17357

Vik, S. B., Long, J. C., Wada, T., Zhang, D. , (2000) A Model for the Structure of Subunit a of the Escherichia coli ATP Synthase and its Role in Proton Translocation, Biochim. Biophys. Acta., 1458: 457-466

Vik, S. B. (2000) What is the role of the epsilon subunit of the E. coli ATP synthase J. Bioenergetics Biomembranes 32, 485-491

Long, J. C., DeLeon-Rangel, J. and Vik, S. B. (2002) Characterization of the First Cytoplasmic Loop of Subunit a of the Escherichia coli ATP Synthase by Surface Labeling, Cross-linking and Mutagenesis. J. Biol Chem. 277: 27288-27293.

Zhang, D. and Vik, S. B. (2003) Helix packing in subunit a of the Escherichia coli ATP Synthase as determined by chemical labeling and proteolysis of the cysteine-substituted protein. Biochemistry 42, 331-337

Zhang, D. and Vik, S. B. (2003) Close proximity of a cytoplasmic loop of subunit a with c subunits of the ATP synthase from Escherichia coli. J. Biol. Chem. 278: 12319-12324

Amarneh, B.and Vik, S. B.(2003)  Mutagenesis of Subunit N of the Escherichia coli Complex I. Identification of the Initiation Codon and the Sensitivity of Mutants to Decylubiquinone. Biochemistry 42, 4800-4808.

DeLeon-Rangel J., Zhang D., Vik S. B. (2003) The role of transmembrane span 2 in the structure and function of subunit a of the ATP synthase from Escherichia coli. Arch. Biochem. Biophys. 418, 55-62

Ishmukhametov R. R., Galkin M. A., and Vik S. B. (2005) Ultrafast purification and reconstitution of His-tagged cysteine-less Escherichia coli F₁F_o ATP synthase. Biochim. Biophys. Acta. 1706:110-116.

Amarneh, B. and Vik, S. B. (2005) Direct transfer of NADH from malate dehydrogenase to complex I in Escherichia coli. Cell Biochem. Biophys. 42:251-261.

Vik S. B. and Ishmukhametov R. R. (2005) Structure and function of subunit a of the ATP synthase of Escherichia coli. J. Bioenerg. Biomembr. 37:445-449

Galkin M.A., Ishmukhametov R. R, and Vik S.B. (2006) A functionally inactive, cold-stabilized form of the Escherichia coli F₁F_o ATP synthase. Biochim. Biophys. Acta. 1757:206-214

Vik, S. B. (2006) Re: protons, proteins and ATP. Photosynth Res. 87, 231

Amarneh B., De Leon-Rangel J., and Vik S. B. (2006) Construction of a deletion strain and expression vector for the Escherichia coli NADH:ubiquinone oxidoreductase (Complex I). Biochim. Biophys. Acta. 1757: 1557-1560.

Ganti, S., and Vik S. B. (2007) Chemical modification of mono-cysteine mutants allows a more global look at conformations of the epsilon subunit of the ATP synthase from Escherichia coli. J. Bioenerg. Biomembr.  39: 99-107.

Vik, S. B. (in press 2007). Chapter 3.2.3, ATP Synthase. In A. Böck, R. Curtiss III, J. B. Kaper, F. C. Neidhardt, T. Nyström, K. E. Rudd, and C. L. Squires (ed.), EcoSal—Escherichia coli and Salmonella: cellular and molecular biology. [Online.] http://www.ecosal.org. ASM Press, Washington, D.C.

Vik, S. B. (February 2008). Chapter 2, An analysis of the structure and function of Complex I from Escherichia coli. In M. I. Gonzalelz Siso (ed.), Complex I and Alternative Dehydrogenases. Transworld Research Network, Kerala, India.

Ishmukhametov R. R., Pond, J. B., Al-Huqail, A., Galkin M. A., and Vik S. B. (2008) ATP synthesis without R210 of subunit a in the Escherichia coli F₁F_o ATP synthase. Biochim. Biophys. Acta. 1777: 32-38.

Bae, L., and Vik, S. B. (2009) A more robust version of the Arginine 210-switched mutant in subunit a of the Escherichia coli ATP synthase. Biochim. Biophys. Acta 1787, 1129-1134.