BIOL 6312
Proteins: Structure, Function, and Design
Spring 2003
Instructor: Steven Vik (214) 768-4228
Class: M 1:00-4:00 132DLS
email: svik@mail.smu.edu
WWW: http://svik.life.smu.edu or faculty.smu.edu/svik
Tentative Schedule
| Date |
Topics
|
Readings:Branden&Tooze | |
| Jan 13 | Introduction/Secondary Structure | Ch 1-2 | |
| Jan 20 | Holiday | ||
| Jan 27 | Properties of Amino Acids | HW#1 | Ch 1-2 |
| Feb 3 | Structural motifs, All-a folds, coiled-coils 3:00PM Computer lab | HW#2 (text) | Ch 3 |
| Feb 10 | a/b Folds 3:00PM Computer lab | Ch 4 | |
| Feb 17 | All b folds | HW#3 | Ch 5 |
| Feb 24 | Purification and Structure determination | Ch 18 | |
| Mar 3 | Midterm exam | ||
| Mar 10 | Spring Break | ||
| Mar 17 | Predictions of Structure | HW#4 | Ch 17 |
| Mar 24 | Protein Folding, Prions | template | Ch 6 |
| Mar 31 | Thermostability,TATA binding protein | Ch 9 | |
| Apr 7 | Membrane proteins-Bacteriorhodopsin | Ch 12 | |
| Apr 14 | Membrane proteins, fusion | Ch 12, 5 | |
| Apr 21 | G proteins, motor proteins | Ch 13 | |
| Apr 28 | Protein design, Serine proteases | Ch 17, 11 |
The text for the course:
Introduction to Protein Structure (1999), 2nd ed.
Carl Branden and John Tooze
Other reading material will be provided.
Grading will be based on one exam, given at midterm, probably March 3 (1/3), several homework assignments, primarily involving analysis of proteins by computer (1/3), and a review paper with web tutorial describing recent studies of a protein, a group of related proteins or a new approach to the study of proteins, etc., due May 5, Monday of Finals week, at 1 PM (1/3). The topic should be chosen in consultation with the instructor. Sample topics will be provided later.
Link to Final Project Description-PDF file
Comments/questions: svik@mail.smu.edu
Copyright 2003, Steven B. Vik, Southern Methodist University