17 February 2003

Biol 6312

Homework#3

All b Structures

See Chime tutorial of examples here

These are protein folds in which the primary fold contains only b-strands.

There are 3 main classes containing antiparallel strnads:

1. Up and down antiparallel b barrel

2. Greek key

3. Jelly roll

The jelly roll also contains 1 Greek key motif, but has other distinguishing features.

Up and down antiparallel b barrel

The up-and-down beta-barrel proteins

The FASEB Journal, Vol 8, 1240-1247, (1994)

JM LaLonde, DA Bernlohr and LJ Banaszak

Beta Propeller Proteins

Review:

Beta propellers: structural rigidity and functional diversity.

Curr Opin Struct Biol 1999 Dec;9(6):715-21

Fulop V, Jones DT

Greek Key Proteins

Look it up in SCOP: link

Jelly Roll Proteins

See short paper by Thornton Group

Depicting topology and handedness in jellyroll structures.

FEBS Lett 1992 Aug 10;308(1):1-3

Stirk HJ, Woolfson DN, Hutchinson EG, Thornton JM

Beta Helix

Review:

Protein motifs. 3. The parallel beta helix and other coiled folds.

FASEB J 1995 Mar;9(5):335-42

Yoder MD, Jurnak F

New domain motif: the structure of pectate lyase C, a secreted plant virulence factor

Science 1993 Jun 4;260(5113):1503-7

Yoder MD, Keen NT, Jurnak F

Mimicry of ice structure by surface hydroxyls and water of a beta-helix antifreeze protein.

Nature 2000 Jul 20;406(6793):322-4

Liou YC, Tocilj A, Davies PL, Jia Z

Scop for Chime      Right handed Left-handed

A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.

Science 1995 Nov 10;270(5238):997-1000

Raetz CR, Roderick SL