| Substrate binding to anthrax toxin lethal factor
Lethal factor is a protease that attacks the mitogen-activated protein kinase kinase (MAPKK-2), shown in CPK colors. Note the complementarity between the lethal factor and its substrate, a peptide from MAPKK-2. Pannifer, A. D., Wong, T. Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D. B., Collier, R. J., Park, S., Leppla, S. H., Hanna, P., Liddington, R. C.: Crystal Structure of the Anthrax Lethal Factor. Nature 414 pp. 229 (2001) 1jky (PDB) |