Immunoglobulin: Heavy chains in green and yellow, and light chains in red and blue

A single Heavy chain is composed of 4 very similar domains. Each is a beta-sandwich domain composed of 7-8 anti-parallel strands.

This domain has 7 strands. Notice that it has 2 distinct sheets.

There is a Greek key motif in this domain, colored Magenta. Two strands are in one sheet and the 2 are in the other sheet.

1igt (PDB)


Harris, L. J., Larson, S. B., Hasel, K. W., McPherson, A.: Refined structure of an intact IgG2a monoclonal antibody. Biochemistry 36 pp. 1581 (1997) (PubMed)