Welcome to our Research Pages

John G. Wise, Ph.D.

Ph.D.: University of Rochester

Office: 234 -Dedman Life Sciences Building
Tel: 214.768.3426
Fax: 214.768.3955
Email: jwise@smu.edu

Click for my Publications.
P-gp pumping daunorubicin
P-gp with inhibitors bound

See also: Vogel Wise Research Group

Recent press links:


Supercomputers enabling-cancer-drug-discovery

Dynamic models of drug resistance proteins

Video popularizations of our work:
compounding hope video link
Video link to innner workings computer disoveries of MDR inhibitors

Multiple Drug Resistance ProteinsJournal cover page for Biochemistry - Oct- Dec 2015

Drug discovery and optimization for multidrug drug resistant cancers

Structural and Drug Transport Mechanism studies

Small molecule drug docking

Virtual screening technologies for new inhibitors

Rotary Motors from Biology and ATP Synthase Research

Enzymatic mechanism studies

Mechanisms of multisite cooperative catalysis

Mechanisms of ligand binding in complex multisubunit systems

Membrane protein complex ion-pumping mechanisms in coupled membrane systems


Big Problems with Intelligent Design and Discovery Institute

The Discovery Institute visited SMU on September 23, 2010. This was my response the next day.

Lecture: "Down in the Trenches - Gene Families and Effects on Modern Medicine"

A lecture on the Evolution of Cancer and
Problems in Chemotherapies from the SMU Darwin
Celebration's Faculty Forum (9/12/2009)

A Teaching Moment - 100 SMU students in a discussion about Discovery Institute pseudo-science

The Discovery Institute visited SMU on September 23, 2010. This was the discussion we had in my General Education biology class the next day.

Lecture: "Intelligent Design is not Science"

A lecture on Intelligent Design for “The Scientific Method – Critical and Creative Thinking” at the Department of Physics at SMU

Lecture with Prof. Randy Scalise (SMU Physics): "Navigating Science and Pseudoscience"

A lecture on techniques to separate apparent facts from factual reality
Given in the 18th Teaching Effectiveness Symposium at the Center for Teaching Excellence at SMU (8/19/2010)

Biochemistry Links

Websites of interest to the Biomedical community


Evolution Links

Interesting Links on evolutionary topics


John Wise at Biology at SMU

My Teaching Website at the Department of Biological Sciences at SMU website

Biology at SMU

The Department of Biological Sciences at SMU website

Many thanks to the following for support:

The National Institutes of Health
The Communities Foundation of Texas
The SMU University Research Council
The SMU Dedman College Dean's Research Council
The SMU Hamilton Undergraduate Research Scholar Program
The SMU Engaged Learning Program

We would also like to give special thanks to Ms. Suzy Ruff of Dallas, Texas for her enthusiastic and generous support of our work.