Presentations

Buynak, J. D.; Graff, N. M. "Nucleophilic Insertion Reactions of [Bis(trimethylsilyl)-amino}dimethylphosphine with Epoxides and Nitrosoaromatics" 186th American Chemical Society Meeting: Washington, D. C. 1983.

Buynak, J. D.; Pajouhesh, H.; Lively, D. L.; Ramalakshmi, Y.  "TheAddition of Chlorosulfonyl Isocyanate to an Allenyl Acetate:  The Preparation of a Versatile Intermediate for Antibiotic Synthesis" Gordon Research Conference on Natural Products:  1984.

Buynak, J. D. Pajouhesh, H.;  Lively, D. L.; Ramalakshmi, Y.  "The Addition of Chlorosulfonyl Isocyanate to an Allenyl Acetate:  The Preparation of a Versatile Intermediate for Antibiotic Synthesis" 188th American Chemical Society National Meeting:  Philadelphia 1984.

Buynak, J. D.; Rao, M. N.; Chandrasekaran, R. Y.; Finn, K. "a-Alkylidene-b-lactams in Synthesis:  A Formal Synthesis of Asparenomycin C" 190th  American  Chemical Society Meeting: Chicago 1985.

Buynak, J. D.; Rao, M. N. "New Approaches the Syntheses of the Carbapenems:  Carpetimycin A and Asparenomycin C"  Gordon Research Conference on Natural Products: 1985.

Buynak, J. D.; Rao, M. N.: Mathrew, J.; George, C. "Synthetic Utility of a-Alkylidene-b-lactams" 191st  American Chemical Society Meeting:  New York 1986.

Buynak, J. D.; Mathew, J.; Rao, M. N. "Preparation and Use of Silylated a-Alkylidene-b-lactams" XX Organosilicon Symposium New York 1986.

Buynak, J. D.; Mathew, J.; Rao, M. N. "Preparation and Utility of a-(Silylalkylidene)-b-lactams" Gordon Research Conference on Natural Products:  1986.

Buynak, J. D.; Mathew, J.; Pellissier, J.; Rao, M. N. "Preparation and Utility of a-(a'-silylalkylidene)-b-lactams"  Southwest Regional Meeting of the American Chemical Society:  1986.

Buynak, J. D.; Strickland, B. "The Conversion of Acylsilanes into Chiral (Non-Silicon-Containing) Alcohols" XXI Organosilicon Symposium, Philadelphia, 1989.

Buynak, J. D. "Inhibitors of b-Lactamase and Elastase" Rice University, 1997

Buynak, J. D. "Inhibitors of b-Lactamase and Elastase" Aronex Pharmaceutical, Houston 1997

Buynak, J. D. "Inhibitors of b-Lactamase and Elastase" Versicor, Inc., South San Francisco, 1997

Buynak, J. D.; Rao, A. S.; Ford, G. P.; Carver, C.; Adam, G.; Geng, B.; Bachmann, B.; Shobassy, S.; Lackey, S. "7-Alkylidenecephalosporin Esters as Inhibitors of Human Leukocyte Elastase" National Meeting of the American Chemical Society, San Francisco, 1997.

Buynak, J. D.; Rao, A. S. "Synthesis of Bridged Penams" National Meeting of the American Chemical Society, Dallas, 1998.

Buynak, J. D.; Rao, A. S.; Adam, G.; Nidamarthy, S.; Doppalapudi, V. R. “New b-Lactamase Inhibitors with Broad Activity” 38th Interscience Conference on Antimicrobial Agents and Chemotherapy” San Diego, CA, 1998.

Buynak, J. D.; Rao, A. S.; Doppalapudi, V. R.; Adam, G.; Nidamarthy, S. D. “The Synthesis and Evaluation of 6-Alkylidene-2’b-substituted Penicillin Sulfones as b-Lactamase Inhibitors” 3rd International Antibacterial Drug Discovery and Development Summit” Princeton, New Jersey 1999.

Buynak, J. D.; Doppalapudi, V. R.; Frotan, M.; Kumar, R. “Stille Coupling Approaches to the Stereospecific Synthesis of b-Lactamase Inhibitors”, 217th National Meeting of the American Chemical Society, Anaheim CA, 1999.

Buynak, J. D.; Rao, A. S.; Doppalapudi, V. R.; Adam, G.; Nidamarthy, S.; “New b-Lactamase Inhibitors of the Class A and Class C Enzymes” 217th National Meeting of the American Chemical Society, Anaheim CA, 1999.

Buynak, J. D.; Doppalapudi, V. R.; Nidamarthy, S. D.; Adam, G.; Rao, A. S. “New beta-Lactamase Inhibitors” International Congress on b-Lactamase, L’Aquila, Italy 1999.

Buynak, J. D.; Doppalapudi, V. R.; Nidamarthy, S. D.; Adam, G.; Rao, A. S. “Cephalosporins with Improved b -Lactamase Inhibitory Activity” 218th National Meeting of the American Chemical Society, New Orleans, LA, 1999.

Buynak, J. D.; Doppalapudi, V. R.; Nidamarthy, S. D.; Adam, G.; Rao, A. S. “New Cephalosporin-Derived b-Lactamase Inhibitors”, 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco CA 1999.

Buynak, J. D.; Doppalapudi, V. R.; Rao, A. S.; Nidamarthy, S. “New Methodology for the Preparation of b-Lactamase Inhibitors” Joint 55th Southwest and 15th Rocky Mountain Regional American Chemical Society Meeting, El Paso, Texas 1999.

Buynak, J. D.; Doppalapudi, V. R.; Adam, G. “New Cephalosporin-Derived b-Lactamase Inhibitors” 4th International Drug Discovery and Development Summit, Princeton, NJ, 2000.

Crichlow, G. V.; Doppalapudi, V. R.; Buynak, J. D.; Knox, J. R. “Inhibition of the Extended Spectrum Class C b-Lactamase GC1 with Sulfones: Crystallographic and SAR Studies” 219th National Meeting of the American Chemical Society, Washington DC, 2000.

Buynak, J. D.; Doppalapudi, V. R.; Rao, A. S. “New Penicillin and Cephalosporin-derived b-Lactamase Inhibitors” 7th International Conference on Chemistry of Antibiotics and Related Microbial Products (ICCA – 7), Mierki, Poland, 2000.

Crichlow, G. V.; Doppalapudi, V. R.; Buynak, J. D.; Knox, J. R. “Inhibition of the Extended Spectrum Class C b-Lactamase GC1 with Sulfones: Crystallographic and SAR Studies” 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, 2000.

Buynak, J. D.; Doppalapudi, V. R.; Crichlow, G. V.; Knox, J. R. “A Rational Approach to the Design of New b-Lactamase Inhibitors”, 52nd Southeast-56th Southwest Combined ACS Regional Meeting, New Orleans, LA 2000.

Persson, K.; Buynak, J. D.; Strynadka, N. C. J. “Crystallographic, modeling, and SAR Studies of 2’-Substituted-6-alkylidenepenam Sulfones as Inhibitors of the TEM-1 b-lactamase” 221st National American Chemical Society Meeting, San Diego, 2001.

Buynak, J. D.; Vogeti, L.; Chen, H. “Preparation and Utility of 3-Stannylated Cephalosporins” 222nd National American Chemical Society Meeting, Chicago, 2001.

Buynak, J. D.; Solomon, G. M.; Vogeti, L. Chen, H.; Chambers, A.; "Evaluation of 3-substituted cephalosporin sulfones as b-lactamase inhibitors." 223rd National Meeting of the American Chemical Society, Orlando, Fl  2002.

Buynak, J. D. "Synthetic, Mechanistic, and Crystallographic Studies of Compounds to Defeat Bacterial Resistance" University of Texas at Arlington, 2002.

Buynak, J. D. "Unique Inhibitors of the b-Lactamases" Ontogen Corporation, San Diego, 2002.

Buynak, J. D. "The Synthesis and Evaluation of Inhibitors of the Metallo-b-lactamases" Southwest Regional Meeting of the American Chemical Society, Austin, TX, 2002.

Buynak, J. D.; Chen, H.; Vogeti, L.; Buchanan, C.; Gadachanda, V. R. "Dual Inhibitors of the Metallo- and Serine-b-lactamases" 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, 2002.

Buynak, J. D. "Synthetic, Mechanistic, and Crystallographic Studies of Compounds to Defeat Bacterial Resistance" Georgetown University, 2002.

Buynak, J. D. "Synthetic, Mechanistic, and Crystallographic Studies of Compounds to Defeat Bacterial Resistance" AstraZeneca Inc., 2003.

Buynak, J. D. "Synthetic, Mechanistic, and Crystallographic Studies of Compounds to Defeat Bacterial Resistance" University of Kansas, 2003.

Buynak, J. D.; Chen, H.; Vogeti, L.; Gadhachanda, V. R.; Shaw, R. "Unique b-Lactamase Inhibitors That Target Both Metallo- and Serine-b-Lactamases." 224th National Meeting of the American Chemical Society, New Orleans, LA 2003.

Chen, Hansong; Gadhachanda, Venkat Rao; Vogeti, Lakshminarayana; Palzkill, Timothy; Shaw, Robert; Buynak, John D.  Synthesis and activity of cephalosporins that simultaneously inactivate both serine and metallo-b-lactamases.    Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004  (2004),     MEDI-074.

 Buynak, John D.  Starting a Pharmaceutical/Diagnostic Discovery Company.    Abstracts, 60th Southwest Regional Meeting of the American Chemical Society, Fort Worth, TX, United States, September 29-October 4, 2004 (2004),     SEPT04-464.

 Buynak, John D.; Chen, Hansong; Gadhachanda, Venkat Rao.  The synthesis and activity of 7-(mercaptomethyl)cephalosporinates: trifluorothioacetic acid as a mild reagent for the introduction of the mercapto group.    Abstracts, 60th Southwest Regional Meeting of the American Chemical Society, Fort Worth, TX, United States, September 29-October 4, 2004 (2004),     SEPT04-217.

 John D. Buynak, "Synthetic, Mechanistic, and Crystallographic Studies of Compounds Designed to Impede Bacterial Resistance" University of Texas at Dallas, (invited seminar, Keynote speaker at Chemistry and Biology Symposium, 2004).

John D. Buynak, "Synthetic, Mechanistic, and Crystallographic Studies of Compounds Designed to Impede Bacterial Resistance"  Alcon Pharmaceutical (invited seminar, 2004)

 John D. Buynak, "Synthetic, Mechanistic, and Crystallographic Studies of Compounds Designed to Impede Bacterial Resistance"  University of North Texas Health Science Center (invited seminar, 2004

Buynak, John D. "The Design, Synthesis, and Evaluation of Class Selective and also Broad Spectrum Inhibitors of b-Lactamase" Case Western Reserve University (invited seminar, 2004).

Buynak, J. D.; Chen, H.; Gadhachanda, V. R. "The Synthesis and Activity of 7-(Mercaptomethyl)cephalosporinates: Trifluorothioacetic Acide as a Mild Reagent for the Introduction of the Mercapto Group." 60th Southwest Regional Meeting of the American Chemical Society, Fort Worth, TX, (2004).

Buynak, J. D.; Vogeti, L.; Gadhachanda, V. R.; Sheri, A. “2’-Substituted penicillin-derived Inhibitors of b-Lactamase” 229th National American Chemical Society Meeting, San Diego, March 13-Merch17, (2005).

Buynak, J. D.; Chen, H.; Ganta, S.; Sheri, A. "Hitting More than One Target: Inhibitors of Serine- and Metallo-b-lactamases." 230th National American Chemical Society Meeting, Washington D. C. (2005).

Buynak, J. D.; Sheri, A.; Pagadala, S. R. R.; Ganta, S. "The Design and Preparation of Mechanism-Based Inhibitors of Bacterial Enzymes.: 63rd Southwest Regional Meeting of the American Chemical Society, Lubbock, TX (2007).

 

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