Brandilyn Stigler

I am an Assistant Professor in the Department of Mathematics at Southern Methodist University. My research involves the development of a mathematical framework for the reverse engineering of biochemical systems. The models used in this work are time- and state-discrete finite dynamical systems, described by polynomial functions over a finite field. We have developed a novel algorithmic approach for reverse engineering, with tools from computational algebra. This approach uses Groebner-basis techniques to build the set of all finite dynamical systems that fit time series data and to select minimal models from this set. The method has been specifically designed for experimental data from biochemical networks, where the data may take the form of time series of mRNA, protein, and/or metabolite concentrations. This work is currently being applied to an oxidative stress response network in S. cerevisiae and a developmental network in C. elegans embryo.

Contact Information

Department of Mathematics Southern Methodist University 209-C Clements Hall 3200 Dyer Street PO Box 750156 Dallas, TX 75275-0156

Phone: (214) 768-2514 Fax: (214) 768-2355 Email: bstigler at smu . edu

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Research Interests

Systems biology Computational algebra

Reverse-engineering methods Polynomial maps over finite fields

Discrete models of biochemical networks Groebner bases of zero-dimensional ideals

Teaching

Calculus II, Linear Algebra

Fall 2009

Education and Training

2008 2005 2002 1999

Postdoctoral Fellowship (Mentors: Winfried Just, Helen Chamberlin) PhD in Mathematics (Advisor: Reinhard Laubenbacher) M.S. in Mathematics B.S. in Mathematics

Mathematical Biosciences Institute Virginia Tech New Mexico State University New Mexico State University

Columbus, Ohio Blacksburg, Virginia Las Cruces, New Mexico Las Cruces, New Mexico

Tuesday September 08 2009