The Lippert Research Group

Publications Affiliated with SMU:
  1. An, W.; Ryan, L. S.; Reeves, A. G.; Bruemmer, K. J.; Mouhaffel, M.; Gerberich, J. L.; Winters, A.; Mason, R. P.; Lippert, A. R. "A Chemiluminescent Probe for HNO Quantification and Real-time Monitoring in Living Cells." Angew. Chem. Int. Edit. 2018, accepted article. doi:10.1002/anie.201811257


  2. Woods, J. J.; Cao, J.; Lippert, A. R.; Wilson, J. J. "Characterization and Biological Activity of a Hydrogen-Sulfide Releasing Red Light-Activated Ruthenium(II) Complex." J. Am. Chem. Soc. 2018, 140, 12383-12387. doi:10.1021/jacs.8b08695


  3. An, W.; Mason, R. P.; Lippert, A. R. "Energy Transfer Chemiluminescence for Ratiometric pH Imaging." Org. Biomol. Chem. 2018, 16, 4176-4182. doi:10.1039/C8OB00972D


  4. Cao, J.; An, W.; Reeves, A. G.; Lippert, A. R. "A Chemiluminescent Probe for Cellular Peroxynitrite Using a Self-Immolative Oxidative Decarbonylation Reaction." Chem. Sci. 2018, 9, 2552-2558. doi:10.1002/anie.201711228


  5. Ryan, L. S; Lippert, A. R. "Ultrasensitive Chemiluminescent Detection of Cathepsin B: Insights into the New Frontier of Chemiluminescent Imaging." Angew. Chem. 2018, 57, 622-624. doi:10.1002/anie.201711228 (Highlight Article)

  6. Patel, S. K.; Cao, J.; Lippert, A. R. "A Volumetric Digital Light 3D Photoactivatable Dye Display." Nature Commun. 2017, 15239. doi:10.1039/C7AY01238A [SMU Research] [EurekAlert!] [Phys.Org] [NovusLight] [Optics & Photonics News] [Cosmos Magazine] [Digital Trends]


  7. Kroll, J. L.; Werchan, C. A.; Reeves, A. G.; Bruemmer, K. J.; Lippert, A. R.; Ritz, T. "Sensitivity of salivary hydrogen sulfide to psychological stress and its association with exhaled nitric oxide and affect." Physiol. Behav. 2017, 179, 99-104. doi:10.1016/j.physbeh.2017.05.023


  8. Reeves, A. G.; Subbarao, M.; Lippert, A. R. "Imaging acetaldehyde formation during ethanol metabolism in living cells using a hydrazine naphthalimide fluorescent probe." Anal. Methods 2017, 9, 3418-3421. doi:10.1039/C7AY01238A


  9. Lippert, A. R. "Unlocking the Potential of Chemiluminescence Imaging." ACS Cent. Sci. 2017 3, 269-271. doi:10.1021/acscentsci.7b00107 (First Reactions)


  10. Lippert, A. R.*; Cao, J. "1-(Cyanomethyl)tetrahydro-1H-thiophen-1-ium Bromide." e-EROS Encyclopedia of Reagents for Organic Synthesis 2016 1-4. doi:10.1002/047084289X.rn01962


  11. Quimbar, M.E.; Krenek, K. M.; Lippert, A. R.* "A chemiluminescent platform for smartphone monitoring of H2O2 in human exhaled breath condensates." Methods 2016, 109, 123. doi:10.1016/j.ymeth.2016.05.017

    TOC Graphic Smartphone.jpg

  12. Cao, J.; Campbell, J.; Liu, L.; Mason, R. P.; Lippert, A. R.* "In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation." Anal. Chem. 2016, 88, 4995. doi:10.1021/acs.analchem.6b01096

    TOC Graphic CHS3.jpg

  13. Cao, J.; Lopez, R.; Thacker J. M.; Moon, J. Y.; Jiang, C.; Morris, S. N. S.; Bauer, J. H.; Tao, P.; Mason, R. P.; Lippert, A. R.* "Chemiluminescent Probes for Imaging H2S in Living Animals." Chem. Sci. 2015, 6, 1979. doi: 10.1039/C4SC03516J.

    TOC Graphic CHS3.jpg

  14. Lin, V. S.; Lippert, A. R.*; Chang, C. J.* "Azide-Based Fluoresent Probes: Imaging Hydrogen Sulfide in Living Systems." Methods Enzymol. 2015, 1264, 231. doi: 10.1016/bs.mie.2014.11.011.


  15. Lippert, A. R.*; Dickinson, B. C.; New, E. J. "Chapter 21: Imaging Mitchondrial Hydrogen Peroxide in Living Cells." Methods Mol. Biol. 2015, 554, 63. doi: 10.1007/978-1-4939-2257-4_21.


  16. Bruemmer, K. J.; Merrikhihaghi, S.; Lollar, C. T.; Morris, S. N. S.; Bauer, J. H.; Lippert, A. R.* "19F Magnetic Resonance Probes for Detecting Peroxynitrite in Living Cells Using an Oxidative Decarbonylation Reaction." Chem. Commun. 2014, 50, 12311. doi: 10.1039/C4CC04292A

    5-fluoroisatin is now commercially available from Sigma-Aldrich!


  17. Lippert, A. R.* "Designing Reaction-Based Fluorescent Probes for Selective Hydrogen Sulfide Detection." J. Inorg. Biochem. 2014, 133, 136. doi: 10.1016/j.jinorgbio.2013.10.010


  18. Lollar, C. T.; Krenek, K. M.; Bruemmer, K.J.; Lippert, A. R.* "Ylide Mediated Carbonyl Homologations for the Preparation of Isatin Derivatives." Org. Biomol. Chem. 2014, 12, 406. doi: 10.1039/C3OB42024H.


  19. Lin, V. S.; Lippert, A. R.; Chang, C. J.* "Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production." Proc. Natl. Acad. Sci. USA 2013, 110, 7131. doi: 10.1073/pnas.1302193110 (Highlighted in the April 22 issue of Chemical & Engineering News)

    SF7-AM is now commercially available from Sigma-Aldrich!


  1. Wise, J. G.; Vogel, P. D.; Lippert, A. R.; Nanyakkara, A. K.; Aljowni, M. A. (Southern Methodist University) "Inhibitors of Multidrug Resistance Transporter P-Glycoprotein." U.S. Patent Application 15,911,441, filed July 5, 2018.

  2. Patel, S. K.; Lippert, A. R. (Southern Methodist University) "System and Method for a Three-Dimensional Optical Switch Display (OSD) Device." U.S. Patent Application 62,293,128, filed October 7, 2016.

  3. Terrell, J. B.; Lippert, A. R.; Raicevic, S. (LMG Innovations, LLC) "Chemiluminescent Spray and Methods Related Thereto." U.S. Provisional Patent Application 62,331,896, filed May 19, 2016.

  4. Krenek, K. M.; Lippert, A. R. (Southern Methodist University) "Composition, Device and Imaging System for Analysis Using Chemiluminescent Probes", U.S. Patent Application 14,741,141, filed June 16, 2015.

  5. Lippert, A. R.; Chang, C. J. (The Regents of The University of California, Oakland, CA) "Compositions and Methods for Imaging", U.S. Patent 13,816,620, filed August 22, 2011, and issued August 15, 2013.

  6. Lippert, A. R.; Lin, V.; Chang, C. J. (The Regents of The University of California, Oakland, CA) "Fluorescent Probes for Reactive Sulfur Species", U.S. Patent 13,493,253, filed June 10, 2011, and issued Dec 27, 2012.

Publications Unaffiliated with SMU:
  1. Michel, B. W.; Lippert, A. R.; Chang, C. J.* "A Reaction-Based Fluorescent Probe for Selective Imaging of Carbon Monoxide in Living Cells Using a Palladium- Mediated Carbonylation." J. Am. Chem. Soc. 2012 , 124, 15668.

  2. Lippert, A. R.; Van De Bittner, G. C.; Chang, C. J.* "Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems." Acc. Chem. Res. 2011 , 47, 793.

  3. Lippert, A. R.; New, E. J.; Chang, C. J.* "Reaction-Based Fluorescent Probes for the Selective Imaging of Hydrogen Sulfide in Living Cells." J. Am. Chem. Soc. 2011 , 133, 10078. (Highlighted in the October 17 issue of Chemical & Engineering News)

  4. Lippert, A. R.; Keshari, K. R.; Kurhanewicz, J.; Chang, C. J.* "A Hydrogen Peroxide Responsive Hyperpolarized 13C MRI Contrast Agent." J. Am. Chem. Soc. 2011 , 133, 3776.

  5. Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W.* "Synthesis of Phototrappable Shapeshifting Molecules for Adaptive Guest Binding." J. Am. Chem. Soc. 2010 , 132, 15790.

  6. Lippert, A. R.; Gschneidtner, T.; Chang, C. J.* "Lanthanide-Based Luminescent Probes for Selective Time- Gated Detection of Hydrogen Peroxide in Water and Living Cells." Chem. Commun. 2010 , 46, 7510.

  7. Lippert, A. R.; Keleshian, V. L.; Bode, J. W.* "Dynamic Supramolecular Complexation by Shapeshifting Organic Molecules." Org. Biomol. Chem. 2009 , 7, 1529.

  8. Ju, L.; Lippert, A. R.; Bode, J. W.* "Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C- Terminal Peptide alpha-Ketoacids." J. Am. Chem. Soc. 2008 , 130, 4253.

  9. Lippert, A. R.; Kaeobamrung, J.; Bode, J. W.* "Synthesis of Oligosubstituted Bullvalones: Shapeshifting Molecules Under Basic Conditions." J. Am. Chem. Soc. 2006 , 128, 14738.

  10. Khidekel, N.; Arndt, S.; Lamarre-Vincent, N.; Lippert, A.; Poulin-Kerstien, K. G.; Ramakrishnan, B.; Qasba, P. K.; Hsieh-Wilson, L. C.* "A Chemoenzymatic Approach toward Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications." J. Am. Chem. Soc. 2003 , 125, 16162.